Patient presented with atopic lesion on right wrist. Case history on the modalities showed that the itching was worse on heat and better on cold application. This gave us preliminary homeopathic remedies of either apis or sulphur. Further history informed that there is no aggravation from being wet and the patient has a stinging type of pain; this confirmed Apis. Patient was also given the proprietary oral drops of atopy and allergy combo along with homeopathic remedy Staph 1M. Staph 1m was required as the patient had a secondary infection along with atopic lesion.After 1 week of treatment the atopic lesion resolved.